The Association Between Dietary Iron, the SNP of the JAZF1 rs864745, and Glucose Metabolism in a Chinese Population.

OBJECTIVES: Dysglycemia is prevalent in China; previous studies had shown that dietary iron was associated with glucose metabolism, and rs864745 was also related to it. The objective of this study is to investigate the association between dietary iron, the SNP of the JAZF1 rs864745, and glucose metabolism among Chinese adults. METHODS: 3298 participants (1584 males and 1714 females) were recruited and underwent physical measurements, laboratory tests, and genotyping. All surveys were conducted by qualified public health professionals. Dietary iron was assessed using the 3-day 24 h dietary recall method and condiment weight records. Genotyping for rs864745 was performed using the SNaPshot Multiplex System. RESULTS: After adjusting for covariates, a significant trend was found between the dietary iron and elevated fasting glucose (p = 0.012), whereas no such trend was observed for the rs864745 (p = 0.932). Among the male participants, the risk of elevated fasting glucose was associated with both dietary iron (compared to the lowest quartile, the ORs with 95% CIs for elevated fasting glucose in Q2,Q3, and Q4 were 1.52 (1.01, 2.45), 1.73 (1.05, 3.00), and 2.49 (1.33, 4.74), respectively) and the rs864745 (OR = 2.15 (1.02, 4.51)), and an interaction effect between them was observed (p = 0.041), which was absent in females (p = 0.999 and p = 0.131, respectively). Stratified by the SNP rs864745, the males without the C allele had a linear risk increase with iron (p = 0.018), while the C allele carriers did not. Additionally, ferritin and the rs864745 were associated with the AST-to-ALT ratio (p = 0.005 and p = 0.048, respectively). CONCLUSIONS: Our study found that dietary iron and the SNP rs864745 interacted and were associated with elevated fasting glucose in Chinese males and absent in females. In addition, the presence of a C allele on rs864745 showed higher risks of elevated fasting glucose regardless of the consumption of dietary iron among the males.