Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we found that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions developed from a few highly mutated clones that dominate most of the bronchial tree. Multisite sequencing in human patients confirmed the presence of clonally related preinvasive lesions across distinct airway regions. Our work identifies a transition in basal cell clonal dynamics, and an associated shift in basal cell fate, as drivers of field cancerization in the lung.
Aberrant basal cell clonal dynamics shape early lung carcinogenesis.
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作者:Gómez-López Sandra, Alhendi Ahmed S N, Przybilla Moritz J, Bordeu Ignacio, Whiteman Zoe E, Butler Timothy, Rouhani Maral J, Kalinke Lukas, Uddin Imran, Otter Kate E J, Chandrasekharan Deepak P, Lebrusant-Fernandez Marta, Shurr Abigail Y L, Durrenberger Pascal F, Moore David A, Falzon Mary, Reading James L, Martincorena Iñigo, Simons Benjamin D, Campbell Peter J, Janes Sam M
期刊: | Science | 影响因子: | 45.800 |
时间: | 2025 | 起止号: | 2025 Jun 12; 388(6752):eads9145 |
doi: | 10.1126/science.ads9145 |
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