Crystal structures of binary compounds of meldonium 3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)prop-ano-ate with sodium bromide and sodium iodide.

3-(1,1,1-Tri-methyl-hydrazin-1-ium-2-yl)propano-ate (C(6)H(14)N(2)O(2), M, more commonly known under its commercial names Meldonium or Mildronate) co-crystalizes with sodium bromide and sodium iodide forming polymeric hydrates poly[[tetra-μ-aqua-di-aqua-bis-[3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)propano-ate]disodium] dibromide tetra-hydrate], [Na(2)(C(6)H(14)N(2)O(2))(2)(H(2)O)(6)]Br(2)·4H(2)O, and poly[[di-μ-aqua-di-aqua-[μ-3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)propano-ate]disodium] diiodide], [Na(2)(C(6)H(14)N(2)O(2))(2)(H(2)O)(4)]I(2). The coordination numbers of the sodium ions are 6; the coordination polyhedra can be described as distorted octa-hedra. Metal ions and M zwitterions are assembled into infinite layers via electrostatic inter-actions and hydrogen-bonded networks. These layers are connected via electrostatic attraction between halogenide ions and positive tri-methyl-hydrazinium groups into a three-dimensional structure.