Prenylated Flavonoids from the Roots of Tephrosia rhodesica.

Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)-CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 μg and IC(50) = 5-15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.