Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

体外脑内皮细胞和急性肝衰竭小鼠脑中 occludin 和 claudin-5 的破坏

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作者:Feng Chen, Norifumi Ohashi, Wensheng Li, Christopher Eckman, Justin H Nguyen

Conclusion

TJ proteins are significantly perturbed in brains of mice with ALF. These data corroborate the important role of MMP-9 in the vasogenic mechanism of brain edema in ALF.

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