Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats.

BACKGROUND: A considerable amount of attention has been recently paid to the discovery of effective natural antidiabetic drugs. Terminalia chebula is considered as the mother of herbs, with reported antidiabetic activity. This study aims to evaluate the renal and hepatic protective profile of its antidiabetic therapeutic doses. METHODS: To achieve the aim of the study, a total of 66 adult male rats of Sprague-Dawley species weighing about 180-200 g (weighed using a digital scale) were used. Type 2 diabetes mellitus (T2DM) was induced in using streptozotocin (STZ), rats were given a 5% dextrose solution for the next 24 h. Subjects received oral treatment of Terminalia chebula ethanolic extract at different doses (200, 400, and 600 mg/kg body weight) for 28 days. Measurements of fasting blood glucose level, change in body weight, lipid profile, serum liver enzymes, serum renal parameter, and histopathology of liver and kidney were carried out. RESULTS: Higher doses of Terminalia chebula (600 mg/Kg) were shown to have a potential therapeutic effect as well as the most prominent antidiabetic, antilipidemic activity, hepatoprotective and renoprotective profiles when compared to lower doses. CONCLUSION: The use of Terminalia chebula alone or in combination with conventional antidiabetic drugs may be beneficial as a new advent therapy for diabetes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-021-00951-8.