A quantitative comparison of five optical coherence tomography angiography systems in clinical performance.

AIM: To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVue™, AngioPlex™, Spectralis(®) OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT Angio™. METHODS: Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm(2) scan pattern (Spectralis OCTA for 3×3 mm(2) scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance (ANOVA) with Bonferroni's post-test and Friedman test with Dunn's post-test were used to compare measurements. RESULTS: The age of the subjects was 28.19±5.55y (range, 23-49y). The spherical equivalent refraction was -2.55±1.84 D (range, 0.00 to -5.25 D). Significant difference was observed in the evaluation of vessel valid visibility (AngioVue the highest: 0.111±0.031 for 3×3 mm(2) scan and 0.128±0.020 for 6×6 mm(2) scan), number of motion artifacts (AngioVue the fewest: 0.778±1.086 for 3×3 mm(2) scan and 0.333±0.620 for 6×6 mm(2) scan) and acquisition time (AngioPlex the shortest: 8.537±1.921s for 3×3 mm(2) scan and 8.298±1.741s for 6×6 mm(2) scan; all P<0.001). CONCLUSION: There is poor agreement of measurements among systems. AngioVue provides images with the highest vessel valid visibility and the fewest motion artifacts. AngioPlex achieves the shortest acquisition.