Unilateral chemical ablation of the adrenal gland lowers blood pressure and alleviates target organ damage in spontaneously hypertensive rats

单侧肾上腺化学消融可降低自发性高血压大鼠的血压并减轻靶器官损害

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作者:Xinquan Wang #, Tao Luo #, Yi Yang, Yaqiong Zhou, Jixin Hou, Peijian Wang

Conclusion

Unilateral debulking of the adrenal gland using ethanol ablation is a promising therapeutic strategy for treating hypertension.

Methods

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were subjected to unilateral adrenal ablation with injection of ethanol or a sham procedure. Blood pressure was monitored for 24 weeks.

Results

Adrenal ablation significantly lowered systolic and diastolic blood pressure of SHR but not WKY from 4 to 24 weeks after the procedure.

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