Unilateral chemical ablation of the adrenal gland lowers blood pressure and alleviates target organ damage in spontaneously hypertensive rats
单侧肾上腺化学消融可降低自发性高血压大鼠的血压并减轻靶器官损害
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作者:Xinquan Wang #, Tao Luo #, Yi Yang, Yaqiong Zhou, Jixin Hou, Peijian Wang
| 期刊: | Hypertension Research | 影响因子: | 4.300 |
| 时间: | 2023 | 起止号: | 2023 Dec;46(12):2693-2704. |
| doi: | 10.1038/s41440-023-01444-2 | 研究方向: | 心血管 |
| 疾病类型: | 高血压 | |
Conclusion
Unilateral debulking of the adrenal gland using ethanol ablation is a promising therapeutic strategy for treating hypertension.
Methods
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were subjected to unilateral adrenal ablation with injection of ethanol or a sham procedure. Blood pressure was monitored for 24 weeks.
Results
Adrenal ablation significantly lowered systolic and diastolic blood pressure of SHR but not WKY from 4 to 24 weeks after the procedure.
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