Weakly nonlinear propagation of focused ultrasound in bubbly liquids with a thermal effect: Derivation of two cases of Khokolov-Zabolotskaya-Kuznetsoz equations.

A physico-mathematical model composed of a single equation that consistently describes nonlinear focused ultrasound, bubble oscillations, and temperature fluctuations is theoretically proposed for microbubble-enhanced medical applications. The Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation that has been widely used as a simplified model for nonlinear propagation of focused ultrasound in pure liquid is extended to that in liquid containing many spherical microbubbles, by applying the method of multiple scales to the volumetric averaged basic equations for bubbly liquids. As a result, for two-dimensional and three-dimensional cases, KZK equations composed of the linear combination of nonlinear, dissipation, dispersion, and focusing terms are derived. Especially, the dissipation term depends on three factors, i.e., interfacial liquid viscosity, liquid compressibility, and thermal conductivity of gas inside bubbles; the thermal conduction is evaluated by using four types of temperature gradient models. Finally, we numerically solve the derived KZK equation and show a moderate temperature rise appropriate to medical applications.