Levels and health risk assessments of Phthalate acid esters in indoor dust of some microenvironments within Ikeja and Ota, Nigeria.

The levels, profiles of Phthalate acid esters (PAEs) and their associated health risk in children and adults using indoor dust samples were assessed from nine (9) microenvironments in Nigeria. Six PAEs congeners were determined using Gas Chromatography-Mass Spectrometry and the human health risk assessments of PAEs exposure to children and adults were computed using the United States Environmental Protection Agency (USEPA) exposure model. The mean concentrations of the total PAEs (Σ(6)PAEs) in indoor dust across the study locations ranged from 1.61 ± 0.12 to 53.3 ± 5.27 μg/g with 72.0% of di-n-octyl phthalate (DnOP) as the most predominant contributor of PAEs in sample locations B, C, D, E, F and G. PAEs estimated daily intake results exceeded the USEPA value of 20 and 50 kg/bw/day for children and adults respectively in some locations. Non-carcinogenic risk exposure indicated no risk (HI < 1), while the carcinogenic risk was within the recommended threshold of 1.00 × 10(-4) to 1.00 × 10(-6) for benzyl butyl phthalate and bis-2-ethylhexyl phthalate. From our findings, lower levels of PAEs were observed in locations with good ventilation system. Also, the human health risk evaluation indicated indoor dust ingestion as the dominant exposure route of PAEs for both children and adults, while the children were at a higher risk of PAEs exposure. To protect children susceptible to these endocrine-disrupting pollutants, soft vinyl children's toys and teething rings should be avoided. Appropriate policies and procedures on the reduction of PAEs exposure to humans should be enacted by all stakeholders, including government regulatory agencies, industries, school administrators and the entire community.