Exploring the Electronic Influence on Coordination Complexes formed from appended Pyrrolidine Azothioformamide Ligands and Copper(I) salts.

Redox-active arylazothioformamide (ATF) ligands have seen attention through their unique coordination complexes formed with late transition metals and their known ability to oxidatively dissolve zerovalent metals. When mixed with Cu(I) salts, ATF ligands form both 2:1 and 2:2 coordination complexes remaining neutral without undergoing any redox event. Herein, a series of para-substituted pyrrolidine-ATFs were synthesized, incorporating both electron-donating groups (i.e., -OMe and -Me) as well as electron-withdrawing groups (i.e., -CF(3), and -CN). These ligands were then mixed with Cu(I) salts, including CuBr, CuI, and [(CH(3)CN)(4)Cu](BF(4)) to form coordination complexes. The resulting complexes underwent thorough characterization, with several producing X-ray quality crystals for detailed structural analysis. Both strong and weak intermolecular interactions were found through Hirshfeld surface analysis and the redox activity of the complexes was probed using cyclic voltammetry in the voltage range of -1.8 to 1.8 V. Through a UV-vis titration study, the binding interactions between the ligand host and Cu(I) metal salt guest molecules were determined and ranged from 4,000 - 100,000 M(-1). Computational modeling was employed to calculate the change in Gibbs free energy (ΔG) for the formation of the complexes, revealing the optimal orientations between the ligand and the metal. These studies have confirmed that para-substituted pyrrolidine-ATFs containing electron-donating groups exhibit a higher binding affinity towards Cu(I) metal salts compared to those with electron-withdrawing groups. With a thorough understanding of ATF-metal coordination, further ligand design can lead to exciting new catalysts and/or selective metal dissolution agents.