miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling

miR-5089-5p 通过 miR-5089-5p/SPINK1/MAPK/MMP9 信号抑制去势抵抗性前列腺癌对恩杂鲁胺的耐药性和转移

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作者:Zhi-Chao Wang, Yan Li, Ke-Liang Wang, Lu Wang, Bo-Sen You, Dan-Feng Zhao, Zhong-Qing Liu, Rui-Zhe Fang, Jia-Qi Wang, Wei Zhang, Jin-Ming Zhang, Wan-Hai Xu

Methods

The expression of SPINK1 in Enz-resistant prostate cancer (PCa) cell lines was detected through next-generation sequencing data and metastatic PCa patients. In vivo and in vitro experiments were performed to investigate the role of SPINK1 in Enz-resistance and metastasis.

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