(99m)Tc-N4-guanine ((99m)Tc-N4amG) was synthesized and evaluated in this study. Cellular uptake and cellular fraction studies were performed to evaluate the cell penetrating ability. Biodistribution and planar imaging were conducted in breast tumor-bearing rats. Up to 17%ID uptake was observed in cellular uptake study with 40% of (99m)Tc-N4amG was accumulated in the nucleus. Biodistribution and scintigraphic imaging studies showed increased tumor/muscle count density ratios as a function of time. Our results demonstrate the feasibility of using (99m)Tc-N4amG in tumor specific imaging.
â¹â¹mTc-N4amG: synthesis biodistribution and imaging in breast tumor-bearing rodents.
阅读：5
作者：Tsao Ning, Chanda Mithu, Yu Dong-Fang, Kurihara Hiroaki, Zhang Yin-Han, Mendez Richard, Yang David J
| 期刊： | Applied Radiation and Isotopes | 影响因子： | 1.800 |
| 时间： | 2013 | 起止号： | 2013 Feb;72:105-13 |
| doi： | 10.1016/j.apradiso.2012.07.018 | ||
特别声明
1、本文转载旨在传播信息，不代表本网站观点，亦不对其内容的真实性承担责任。
2、其他媒体、网站或个人若从本网站转载使用，必须保留本网站注明的“来源”，并自行承担包括版权在内的相关法律责任。
3、如作者不希望本文被转载，或需洽谈转载稿费等事宜，请及时与本网站联系。
4、此外，如需投稿，也可通过邮箱info@biocloudy.com与我们取得联系。