Given the urgent need for alternative strategies to block metastasis progression, we demonstrate that blocking HER2-mediated secondary metastasis improves clinical outcome and establish HER2 as a biomarker for bone metastasis in patients with initial HR+/HER2- breast cancer, which represents â¼70% of all cases.
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2- Breast Cancer.
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作者：Alam Rahat, Reva Anna, Edwards David G, Lege Bree M, Munoz-Arcos Laura S, Reduzzi Carolina, Singh Swarnima, Hao Xiaoxin, Wu Yi-Hsuan, Tian Zeru, Natalee Laura M, Damle Gargi, Demircioglu Deniz, Wang Yixian, Wu Ling, Molteni Elisabetta, Hasson Dan, Lim Bora, Gugala Zbigniew, Chipuk Jerry E, Lang Julie E, Sparano Joseph A, Cheng Chonghui, Cristofanilli Massimo, Xiao Han, Zhang Xiang H-F, Bado Igor L
| 期刊： | Cancer Discovery | 影响因子： | 33.300 |
| 时间： | 2025 | 起止号： | 2025 Apr 2; 15(4):818-837 |
| doi： | 10.1158/2159-8290.CD-23-0543 | ||
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