The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.
Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation.
通过气管内接种增强 Omicron BA.1 在仓鼠体内的致病性
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作者:Port Julia R, Yinda Claude Kwe, Ruckel Claire, Schulz Jonathan E, Smith Brian J, Shaia Carl I, Munster Vincent J
| 期刊: | npj Viruses | 影响因子: | 0.000 |
| 时间: | 2024 | 起止号: | 2024 Jan 16; 2(1):3 |
| doi: | 10.1038/s44298-023-00012-2 | ||
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