PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

PPT1 促进肿瘤生长，是癌症中氯喹衍生物的分子靶点

阅读：6

作者：Vito W Rebecca #, Michael C Nicastri #, Colin Fennelly, Cynthia I Chude, Julie S Barber-Rotenberg, Amruta Ronghe, Quentin McAfee, Noel P McLaughlin, Gao Zhang, Aaron R Goldman, Rani Ojha, Shengfu Piao, Estela Noguera-Ortega, Alessandra Martorella, Gretchen M Alicea, Jennifer J Lee, Lynn M Schuchter,

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2019

起止号：

2019 Feb;9(2):220-229.

doi：

10.1158/2159-8290.CD-18-0706

研究方向：

肿瘤

Significance

This study identifies PPT1 as the previously unknown lysosomal molecular target of monomeric and dimeric CQ derivatives. Genetic suppression of PPT1 impairs tumor growth, and PPT1 levels are elevated in cancer and associated with poor survival. These findings provide a strong rationale for targeting PPT1 in cancer. This article is highlighted in the In This Issue feature, p. 151.

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