To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin.
Association of Pasteurella multocida toxin with vimentin.
多杀性巴氏杆菌毒素与波形蛋白的关联
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作者：Shime Hiroaki, Ohnishi Takahiro, Nagao Kaori, Oka Kiyomasa, Takao Toshifumi, Horiguchi Yasuhiko
| 期刊： | Infection and Immunity | 影响因子： | 2.800 |
| 时间： | 2002 | 起止号： | 2002 Nov;70(11):6460-3 |
| doi： | 10.1128/IAI.70.11.6460-6463.2002 | 研究方向： | 免疫/内分泌 |
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