Conclusion
Subcutaneous immunotherapy (high-dose) could effectively alleviate airway hyperresponsiveness and reduce airway inflammatory infiltration in allergic asthmatic mice.
Objective
The aim of this study was to evaluate the therapeutic effect of subcutaneous injection of high-dose of Humulus pollen allergen on a mouse model of allergic asthma. Method: Humulus pollen-sensitized mice received either regular subcutaneous injections of Humulus pollen allergen extract or control treatment were sacrificed. Airway responsiveness, pulmonary inflammatory cell infiltration, serum cytokine secretion and serum immunoglobulin E (IgE) and G2a (IgG2a) levels were measured. Result: Our