Crystal structure and metabolic activity of 4-(thien-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carb-oxy-lic acid eth-oxy-carbonyl-phenyl-methyl-ester.

4-(噻吩-2-基)-2-甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙氧羰基苯基甲酯的晶体结构和代谢活性

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作者:Mishnev Anatoly, Bisenieks Egils, Mandrika Ilona, Petrovska Ramona, Kalme Zenta, Bruvere Imanta, Duburs Gunars
In the title compound, C(25)H(25)NO(5)S, which exhibits metabolism-regulating activity, the 1,4-di-hydro-pyridine ring adopts a flattened boat conformation while the cyclo-hexenone ring is in an envelope conformation. Mol-ecules in the crystal are assembled into C(6) chains along the a-axis direction via N-H⋯O hydrogen bonds. The thienyl fragment is disordered over two sets of sites in a 0.7220†(19):0.2780†(19) ratio.

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