Kinetic modeling of the behavior of complex chemical and biochemical systems is an effective approach to study of the mechanisms of the process. A kinetic model of coronaviral infection development with a description of the dynamic behavior of the main variables, including the concentration of viral particles, affected cells, and pathogenic microflora, is proposed. Changes in the concentration of hydrogen ions in the lungs and the pH -dependence of carbonic anhydrase activity (a key breathing enzyme) are critical. A significant result is the demonstration of an acute bifurcation transition that determines life or system collapse. This transition is connected with exponential growth of concentrations of the process participants and with functioning of the key enzyme carbonic anhydrase in development of toxic effects. Physical and chemical interpretations of the therapeutic effects of the body temperature rise and the potential therapeutic effect of "thermoheliox" (respiration with a thermolized mixture of helium and oxygen) are given. The phenomenon of "thermovaccination" is predicted, which involves stimulation of the immune response by "thermoheliox".
Chemical kinetics of the development of coronaviral infection in the human body: Critical conditions, toxicity mechanisms, "thermoheliox", and "thermovaccination".
冠状病毒感染在人体内的化学动力学:临界条件、毒性机制、“热氦氧”和“热疫苗接种”
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作者:Varfolomeev Sergey D, Panin Alexander A, Bykov Valeriy I, Tsybenova Svetlana B, Chuchalin Alexander G
| 期刊: | Chemico-Biological Interactions | 影响因子: | 5.400 |
| 时间: | 2020 | 起止号: | 2020 Sep 25; 329:109209 |
| doi: | 10.1016/j.cbi.2020.109209 | 种属: | Human、Viral |
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