Breast cancer is the leading âcause of death from cancer âamong women. Higher âconsumption âof âdietary âmarine n-3 long-chain âpolyunsaturated fatty acids ââ(LC-PUFAs) is associated âwith a ââlower risk of breast âcancer. Eicosapentaenoic âacid (EPA) and âdocosahexaenoic acid (DHA) ââare âtwo n-3 LC-PUFAs found âin fish and exert anticancer âeffects. In this study, ânatural âmarine-âderived âlecithin that is rich in âvarious polyunsaturated fatty acids (PUFAs) was extracted âfrom salmon heads and ââtransformed âinto ânanoliposomes. These ânanoliposomes were âcharacterized and cultured âwith âtwo breast âcancer âlines (MCF-7 and MDA-MB-ââ231). The nanoliposomes âdecreased the âproliferation âand âthe stiffness of both âcancer cell types. These âresults suggest that marine-derived lecithin possesses ââanticancer properties, âwhich may have an impact âon developing new ââliposomal delivery ââstrategies for breast cancer âtreatment.
Effects of âBioactive âMarine-Derived âLiposomes on âTwo âHuman âBreast Cancer ââCell Lines.
生物活性海洋来源脂质体对两种人类乳腺癌细胞系的影响
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作者：Li Jie, Elkhoury Kamil, Barbieux Claire, Linder Michel, Grandemange Stéphanie, Tamayol Ali, Francius Grégory, Arab-Tehrany Elmira
| 期刊： | Marine Drugs | 影响因子： | 5.400 |
| 时间： | 2020 | 起止号： | 2020 Apr 13; 18(4):211 |
| doi： | 10.3390/md18040211 | 种属： | Human |
| 研究方向： | 细胞生物学 | 疾病类型： | 乳腺癌 |
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