Surface-energy dependent contact activation of blood factor XII.

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作者:Golas Avantika, Parhi Purnendu, Dimachkie Ziad O, Siedlecki Christopher A, Vogler Erwin A
Contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution exhibits a parabolic profile when scaled as a function of silanized-glass-particle activator surface energy (measured as advancing water adhesion tension tau(a)(o)=gamma(lv)(o)cos theta in dyne/cm, where gamma(lv)(o) is water interfacial tension in dyne/cm and theta is the advancing contact angle). Nearly equal activation is observed at the extremes of activator water-wetting properties -36

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