4D spectral-spatial computational photoacoustic dermoscopy.

Photoacoustic dermoscopy (PAD) is an emerging non-invasive imaging technology aids in the diagnosis of dermatological conditions by obtaining optical absorption information of skin tissues. Despite advances in PAD, it remains unclear how to obtain quantitative accuracy of the reconstructed PAD images according to the optical and acoustic properties of multilayered skin, the wavelength and distribution of excitation light, and the detection performance of ultrasound transducers. In this work, a computing method of four-dimensional (4D) spectral-spatial imaging for PAD is developed to enable quantitative analysis and optimization of structural and functional imaging of skin. This method takes the optical and acoustic properties of heterogeneous skin tissues into account, which can be used to correct the optical field of excitation light, detectable ultrasonic field, and provide accurate single-spectrum analysis or multi-spectral imaging solutions of PAD for multilayered skin tissues. A series of experiments were performed, and simulation datasets obtained from the computational model were used to train neural networks to further improve the imaging quality of the PAD system. All the results demonstrated the method could contribute to the development and optimization of clinical PADs by datasets with multiple variable parameters, and provide clinical predictability of photoacoustic (PA) data for human skin.