5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. SIGNIFICANCE STATEMENT: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
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作者：Barnes Nicholas M, Ahern Gerard P, Becamel Carine, Bockaert Joël, Camilleri Michael, Chaumont-Dubel Severine, Claeysen Sylvie, Cunningham Kathryn A, Fone Kevin C, Gershon Michael, Di Giovanni Giuseppe, Goodfellow Nathalie M, Halberstadt Adam L, Hartley Rachel M, Hassaine Ghérici, Herrick-Davis Katharine, Hovius Ruud, Lacivita Enza, Lambe Evelyn K, Leopoldo Marcello, Levy Finn Olav, Lummis Sarah C R, Marin Philippe, Maroteaux Luc, McCreary Andrew C, Nelson David L, Neumaier John F, Newman-Tancredi Adrian, Nury Hugues, Roberts Alexander, Roth Bryan L, Roumier Anne, Sanger Gareth J, Teitler Milt, Sharp Trevor, Villalón Carlos M, Vogel Horst, Watts Stephanie W, Hoyer Daniel
| 期刊： | Pharmacological Reviews | 影响因子： | 17.300 |
| 时间： | 2021 | 起止号： | 2021 Jan;73(1):310-520 |
| doi： | 10.1124/pr.118.015552 | ||
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