Assessment by miRNA microarray of an autologous cancer antigen-pulsed adoptive immune ensemble cell therapy (AC-ACT) approach; demonstrated induction of anti-oncogenic and anti-PD-L1 miRNAs

利用 miRNA 微阵列评估自体癌抗原脉冲过继免疫细胞疗法 (AC-ACT) 方法；证实可诱导抗癌和抗 PD-L1 miRNA 的表达

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作者：Masanobu Chinami ,Kaoru Iwabuchi ,Yoshiteru Muto ,Yasuhiko Uchida ,Ryu Arita ,Rana A Shuraim ,Chaker N Adra
期刊：Clin Case Rep影响因子：0.600
时间：2019起止号：2019 Sep 30;7(11):2156-2164.
doi：10.1002/ccr3.2343.

Abstract

A 60-year-old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC-ACT) causing induction of anti-oncogenic and anti-PD-L1 miRNAs as assessed by miRNA microarray. More than 1 year after AC-ACT, metastases have been arrested, and the patient reports good quality of life. Keywords: PD‐1; adoptive cell therapy; cancer; immunotherapy; miRNA analysis.

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