Prolyl-hydroxylase inhibition induces SDF-1 associated with increased CXCR4+/CD11b+ subpopulations and cardiac repair

脯氨酰羟化酶抑制可诱导 SDF-1，与 CXCR4+/CD11b+ 亚群增加和心脏修复相关

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作者：Santhosh Kumar Ghadge,Moritz Messner,Thi Van Pham,Maximilian Doppelhammer,Andreas Petry,Agnes Görlach,Britta Husse,Wolfgang-Michael Franz,Marc-Michael Zaruba
期刊：Journal of Molecular Medicine-Jmm影响因子：
时间：2017起止号：2017 Aug;95(8):825-837.
doi：10.1007/s00109-017-1543-3研究方向： 信号转导

Key messages

DMOG-induced prolyl-hydroxylase inhibition upregulates SDF-1 and CXCR4 in human endothelial cells. Systemic application of DMOG upregulates nuclear HIF-1α and SDF-1 in vivo. Enhanced prolyl-hydroxylase inhibition increases mainly CXCR4+/CD11b+ cells. DMOG increased reparative M2-like CD11b+/CD206+ cells compared to M1-like cells after MI. Enhanced prolyl-hydroxylase inhibition improved cardiac repair and heart function.

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