Gene design, optimization of protein expression and preliminary evaluation of a new chimeric protein for the serological diagnosis of both human and canine visceral leishmaniasis

一种新型嵌合蛋白的基因设计、蛋白表达优化及对人类和犬内脏利什曼病血清学诊断的初步评估

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作者:Wagner J T Santos, Diego H C Tavares, Artur L Castro Neto, Marília B Nascimento, Rafael Dhalia, Alessandra L Albuquerque, Carlos H N Costa, Franklin B Magalhães, Antônio M Rezende, Osvaldo P de Melo Neto

Background

Visceral leishmaniasis (VL) is a major neglected disease, potentially fatal, whose control is still impaired by inefficient and/or expensive treatment and diagnostic

Conclusion

The newly described chimeric protein is potentially useful for the detection of both humans and dogs afflicted with VL, with its use in rapid tests necessary for validation as a new diagnostic tool.

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