We report the complete genome sequences of four parechovirus-A3 (PeV-A3) isolates from Children's Mercy Kansas City (CMKC), United States of America (USA): PeV-A3-MO-12-CMKC/CSF/MO/USA/2012 (isolated in 2012 from cerebrospinal fluid), PeV-A3-8C-CMKC/CSF/MO/USA/2022/ (isolated in 2022 from cerebrospinal fluid), PeV-A3-9C-CMKC/CSF/MO/USA/2022 (isolated in 2022 from cerebrospinal fluid), and PeV-A3-11B-CMKC/Blood/MO/USA/2022 (isolated in 2022 from blood). Sequence analysis revealed multiple mutations throughout the genome of the PeV-A3 isolates in comparison to the prototypic PeV-A3 A308/99 reference sequence (AB084913). Several unique amino acid changes were observed in the PeV-A3 isolates from 2022 that were absent in the PeV-A3 isolate from 2012. Phylogenetic analysis comparison determined that the sequenced PeV-A3 isolates from 2022 cluster together as a separate clade.
Genome Announcement of Four Parechovirus A3 Isolates from the United States of America.
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作者：Dhar Debarpan, Ng Terry Fei Fan, Harrison Christopher J, Rhoden Eric, Mainou Bernardo A, Sasidharan Anjana, VanDonge Katelyn E, Boinpelly Varun Chandra, Selvarangan Rangaraj
| 期刊： | International Journal of Molecular Sciences | 影响因子： | 4.900 |
| 时间： | 2025 | 起止号： | 2025 May 5; 26(9):4378 |
| doi： | 10.3390/ijms26094378 | ||
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