The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

OBJECTIVE: This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients. RESULTS: Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.