Hepatic Adenosine Triphosphate Reduction Through the Short-Chain Fatty Acids-Peroxisome Proliferator-Activated Receptor γ-Uncoupling Protein 2 Axis Alleviates Immune-Mediated Acute Hepatitis in Inulin-Supplemented Mice

通过短链脂肪酸过氧化物酶体增殖激活受体γ-解偶联蛋白2轴减少肝脏三磷酸腺苷可缓解菊粉补充小鼠的免疫介导急性肝炎

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作者:Akihiro Yamaguchi, Toshiaki Teratani, Po-Sung Chu, Takahiro Suzuki, Nobuhito Taniki, Yohei Mikami, Shunsuke Shiba, Rei Morikawa, Takeru Amiya, Ryo Aoki, Takanori Kanai, Nobuhiro Nakamoto

Conclusion

There is a possible unraveled etiopathophysiological link between the maintenance of liver tolerance and dietary fiber. The SCFA-PPARγ-UCP2 axis may provide therapeutic targets for immune-mediated liver injury in the future.

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