Fetal programming effects of pentaerythritol tetranitrate in a rat model of superimposed preeclampsia

季戊四醇四硝酸酯对合并先兆子痫大鼠模型的胎儿编程影响

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Key messages

The core findings of this article suggest that maternal PETN treatment of DSSR, a rat model of a spontaneous superimposed preeclampsia, leads to • Improvement of fetal growth; • No changes of maternal blood pressure or markers of preeclampsia; • Amelioration of HFD-induced glucose intolerance in adult offspring; • No changes in blood pressure development of the offspring on normal chow or high salt-diet; • Potentiation of blood pressure elevation of the offspring on HFD.

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