IL-22 and IL-22-Binding Protein Are Associated With Development of and Mortality From Acute-on-Chronic Liver Failure

IL-22 和 IL-22 结合蛋白与慢性急性肝衰竭的发生和死亡相关

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作者:Katharina Schwarzkopf, Sabrina Rüschenbaum, Samarpita Barat, Chengcong Cai, Marcus M Mücke, Daniel Fitting, Andreas Weigert, Bernhard Brüne, Stefan Zeuzem, Christoph Welsch, Christian M Lange

Conclusion

Our study reveals that high IL-22 levels and low ratios of IL-22BP/IL-22 are associated with ACLF and mortality of patients with cirrhosis. Excessive secretion of IL-22BP can neutralize IL-22 in vitro and may prevent-likely in a context-specific manner-hepatoprotective, but also adverse effects, of IL-22 in patients with cirrhosis.

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