Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer

肿瘤NOS2和COX2与CD8+ T细胞的空间并置促进转移和癌症干细胞微环境的形成,从而导致ER阴性乳腺癌预后不良。

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作者:Lisa A Ridnour #,William F Heinz #,Robert Y S Cheng #,Adelaide L Wink #,Noemi Kedei,Milind Pore,Fatima Imtiaz,Elise L Femino,Ana L Gonzalez,Leandro L Coutinho,Rebecca L Moffat,Donna Butcher,Elijah F Edmondson,Xiaoxian Li,Maria Cristina Rangel,Robert J Kinders,Jens Rittscher,Stanley Lipkowitz,Stephen T C Wong,Stephen K Anderson,Daniel W McVicar,Sharon A Glynn,Timothy R Billiar,Jenny C Chang,Stephen M Hewitt,Stefan Ambs,Stephen J Lockett,David A Wink

Abstract

This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.

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