Survivin Promotes Stem Cell Competence for Skin Cancer Initiation
Survivin促进干细胞能力,从而启动皮肤癌
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作者:Sara Canato,Rahul Sarate,Sofia Carvalho-Marques,Raquel Maia Soares,Yura Song,Sara Monteiro-Ferreira,Pauline Vieugué,Mélanie Liagre,Giancarlo Grossi,Erik Cardoso,Christine Dubois,Edward M Conway,Silvia Schenone,Adriana Sánchez-Danés,Cédric Blanpain
| 期刊: | Cancer Discov | 影响因子: | 29.700 |
| 时间: | 2025 | 起止号: | 2025 Feb 7;15(2):427-443. |
| doi: | PMC7617290 |
Abstract
This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.
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