Background and purpose
Enhanced remyelination of the regenerated axons
Conclusion
These results suggest that BBR may enhance L1 expression and promote axonal remyelination after spinal root avulsion.
Methods
The surgical procedures were performed to build the rat brachial plexus avulsion and re-implantation model, and then, the rats were treated with BBR. After the rehabilitation for 12 weeks, the musculocutaneous nerves were collected for quantitative real-time PCR, Western blot analysis, and histochemical and immunofluorescence staining.
Purpose
Enhanced remyelination of the regenerated axons
Results
We observed that, BBR treatment ameliorated the abnormal musculocutaneous nerve fibers morphology, up-regulated the L1 expression, increased the myelination-related genes, decreased the differentiated-associated genes, and up-regulated the phosphorylation of ERK.