Our landmark discovery of viral mimicry characterized repetitive elements as immunogenic stimuli that cull cancer cells. If expressed repetitive elements cull cancer cells, why does every human cancer express repetitive elements? Our report offers an exciting advancement toward understanding this paradox and how to exploit this mechanism for cancer interception. See related commentary by Murayama and Cañadas, p. 670.
Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.
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作者：Ishak Charles A, Marhon Sajid A, Tchrakian Naïri, Hodgson Anjelica, Loo Yau Helen, Gonzaga Isabela M, Peralta Melanie, Lungu Ilinca M, Gomez Stephanie, Liang Sheng-Ben, Shen Shu Yi, Chen Raymond, Chen Jocelyn, Chatterjee Biji, Wanniarachchi Kevin N, Lee Junwoo, Zehrbach Nicholas, Hosseini Amir, Mehdipour Parinaz, Sun Siyu, Solovyov Alexander, Ettayebi Ilias, Francis Kyle E, He Aobo, Wu Taiyi, Feng Shengrui, da Silva Medina Tiago, Campos de Almeida Felipe, Bayani Jane, Li Jason, MacDonald Spencer, Wang Yadong, Garcia Sarah S, Arthofer Elisa, Diab Noor, Srivastava Aneil, Austin Paul Tran, Sabatini Peter J B, Greenbaum Benjamin D, O'Brien Catherine A, Shepherd Trevor G, Tsao Ming Sound, Chiappinelli Katherine B, Oza Amit M, Clarke Blaise A, Rottapel Robert, Lheureux Stephanie, De Carvalho Daniel D
| 期刊： | Cancer Discovery | 影响因子： | 33.300 |
| 时间： | 2025 | 起止号： | 2025 Apr 2; 15(4):793-817 |
| doi： | 10.1158/2159-8290.CD-24-0094 | ||
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