Baculovirus Display of Peptides and Proteins for Medical Applications

杆状病毒展示肽和蛋白质用于医学应用

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作者:Aaron Pavel Rodríguez-Hernández,Daniel Martínez-Flores,Adolfo Cruz-Reséndiz,Teresa Padilla-Flores,Rodrigo González-Flores,Kenia Estrada,Alicia Sampieri,Aldo Román Camacho-Zarco,Luis Vaca

Abstract

Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.

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