Abstract
Background: This study aims to examine the association between single nucleotide gene polymorphisms (SNPs) of GAB1, GAB2, and GAB3 and the genetic susceptibility to essential hypertension in the Chinese Han population. The findings of this research will contribute to understanding the underlying causes of hypertension. Methods: A community-based sampling survey was conducted in two towns in the south of Jiangsu Province to investigate the correlation between gene polymorphisms and essential hypertension. The study included a total of 2119 cases of hypertension and 2317 healthy controls, with an average follow-up period of 10.75 years. The genotypes of seven tagging SNPs (GAB1 rs300893 and rs11936966, GAB2 rs7107174, rs2450135, and rs3740677, GAB3 rs3813455 and rs5987015) were analyzed. Results: Regression analysis showed that after multifactor correction, only GAB1 rs300893 dominant model was statistically associated with the risk of hypertension among 7 SNPs locis before Bonferroni correction. Subgroup analysis showed that there were associations between specific SNPS and the risk of hypertension in different subgroups, but after Bonferroni correction, these associations were no longer statistically significant. In the follow-up study, Cox proportional hazard regression analysis showed that there was no significant association between the seven SNPs locis and the risk of hypertension. However, subgroup analyses suggest that some gene variants are associated with a reduced or increased risk of hypertension in specific populations. After Bonferroni correction, the addition model of GAB2 rs7107174 was still statistically significant in the specific stratified analysis. Plasma GAB1, GAB2, and GAB3 mRNA expression showed no significant difference between the hypertensive group and the control group. Conclusion: These findings provide additional support for the genetic role of GAB1, GAB2 and GAB3 in hypertension and blood pressure regulation.