Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

法呢醇 X 受体诱导的赖氨酸特异性组蛋白去甲基化酶可降低肝脏胆汁酸水平并保护肝脏免受胆汁酸毒性

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作者:Young-Chae Kim, Sungsoon Fang, Sangwon Byun, Sunmi Seok, Byron Kemper, Jongsook Kim Kemper

Conclusion

This study identifies LSD1 as a novel histone-modifying enzyme in the orchestrated regulation mediated by the farnesoid X receptor and small heterodimer partner that reduces hepatic BA levels and protects the liver against BA toxicity.

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