Abstract
The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (pp<math><mi>p</mi></math>H2)2)<math><mrow><msub><mi></mi><mn>2</mn></msub><mo>)</mo></mrow></math>-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a pp<math><mi>p</mi></math>H22<math><msub><mi></mi><mn>2</mn></msub></math> generator is necessary. Available commercial pp<math><mi>p</mi></math>H22<math><msub><mi></mi><mn>2</mn></msub></math> generators are relatively expensive (EUR 10 000-150 000). To facilitate the spread of pp<math><mi>p</mi></math>H22<math><msub><mi></mi><mn>2</mn></msub></math>-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR <3000<3000<math><mrow><mo><</mo><mn>3000</mn></mrow></math>) 50-bar liquid-nitrogen-cooled pp<math><mi>p</mi></math>H22<math><msub><mi></mi><mn>2</mn></msub></math> generator.