Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma

在卵巢癌中,饥饿失活的mTOR通过ULK1-SH3PXD2A/TKS5-MMP14通路触发细胞迁移

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作者:Chiao-Yun Lin ,Kai-Yun Wu ,Lang-Ming Chi ,Yun-Hsin Tang ,Huei-Jean Huang ,Chyong-Huey Lai ,Chi-Neu Tsai ,Chia-Lung Tsai

Abstract

AMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1. Keywords: MMP14; SH3PXD2A; ULK1; cellular migration; ovarian cancer.

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