PM(2.5) is a key environmental pollutant that induces inflammatory lung injury. Effective prevention and treatment for PM(2).(5)-induced lung damage remain lacking. This study investigated MCC950's protective role in PM(2).(5)-exposed mice and macrophages. PM(2).(5) triggers NLRP3/Caspase-1-mediated pyroptosis, amplifying pulmonary inflammation. MCC950 attenuates injury by inhibiting pyroptosis, suggesting therapeutic potential.
The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM(2.5)-induced acute lung injury by inhibiting alveolar macrophage pyroptosis.
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作者：Han Zhuoxiao, Han Ying, Li Ranran, Fan Kexin, Zhang Xiao, Sun Tengfei, Li Yue, Qiao Hua
| 期刊： | Current Research in Toxicology | 影响因子： | 3.000 |
| 时间： | 2026 | 起止号： | 2026 Jan 22; 10:100282 |
| doi： | 10.1016/j.crtox.2026.100282 | ||
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