The clinical value of FAPI PET/CT in delineating target volumes for nasopharyngeal carcinoma.

PURPOSE: To evaluate the efficacy of (18)F-AIF-NOTA-FAPI-04 PET/CT in improving the accuracy of target volume delineation in nasopharyngeal carcinoma (NPC). METHODS: Automatic delineation of the primary tumor target volume was conducted for 21 newly diagnosed NPC patients using (18)F-AIF-NOTA-FAPI-04 PET/CT images, which applied a threshold-based segmentation with 5% increments from 20 to 60% of SUVmax. Manual delineation of the primary tumor was performed on MRI images. The study analyzed the gross target volumes (GTV) discrepancies between (18)F-AIF-NOTA-FAPI-04 PET/CT and MRI. Furthermore, we compared how the two imaging modalities affected the assessment of the primary tumors' involvement of bone-related structures and soft tissue (mucosa) infiltration. RESULTS: There were variations in the primary tumor target volume across the different imaging methods. There were no significant differences observed between GTV-FAPI 20%, GTV-FAPI 25%, and GTV-FAPI 30% compared to GTV-MRI. Among them, GTV-FAPI 20% showed the closest similarity to GTV-MRI. (18)F-AIF-NOTA-FAPI-04 PET/CT was superior to MRI in detecting soft tissue and bone tissue involvement in primary tumors. CONCLUSIONS: (18)F-AIF-NOTA-FAPI-04 PET/CT enhances precision in delineating GTV for NPC and demonstrates clinical utility in T-staging.