Oroxylin A From Scutellaria baicalensis Improved Pulmonary Fibrosis of Radiation Pneumonia Through Ferroptosis by Nrf2.

Radiation pneumonitis can result in respiratory dysfunction and progress to radiation fibrosis, and in severe cases, respiratory failure may occur. Hence, we investigated the effects of Oroxylin A from Scutellaria baicalensis in radiation pneumonia (RP) and the underlying mechanism. Oroxylin A improved pulmonary fibrosis, reduced oxidative stress, and promoted cell growth in model of RP. Oroxylin A suppressed ferroptosis and induced Nrf2 protein expressions in liver cells of model of RP. Moreover, Nrf2 inhibitor reduced the effects of Oroxylin A on pulmonary fibrosis in model of RP by oxidative stress. Collectively, these data suggest that Oroxylin A from Scutellaria baicalensis improved pulmonary fibrosis of RP through ferroptosis by Nrf2 axle.