Isoquercitrin triggers the ferroptosis of ovarian cancer via SLC7A11-dependent manner to repress its tumorigenesis.

Isoquercitrin (ISOQ) has been identified to exert notable inhibitory effects on tumorigenesis, though its role on ovarian cancer is unknown. Here, this present research focused on the role of ISOQ on ovarian cancer tumorigenesis and investigated its mechanism. Results unveiled that ISOQ dose-dependently repressed the proliferation and migration, and triggered the ferroptosis of ovarian cancer cells. Mechanistically, SLC7A11 functioned as the target of ISOQ, and ISOQ repressed the SLC7A11 expression of ovarian cancer cells. Rescue assays indicated that ISOQ/SLC7A11 accelerated the ferroptosis of ovarian cancer cells. In vivo, ISOQ repressed the tumorigenesis of ovarian cancer cells. Overall, these findings unveiled that ISOQ triggered the ferroptosis of ovarian cancer via SLC7A11-depedent manner to repress its tumorigenesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12672-025-03626-5.