Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer

多组学分析确定了卵巢癌中 N6-甲基腺苷 RNA 修饰相关的关键基因和通路

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作者:Haoya Xu, Xianli Li, Shengtan Wang, Feifei Li, Jian Gao, Limei Yan, Liancheng Zhu

Aims

To explore the pathways and target genes related to N6-methyladenosine (m6A) methylation in ovarian cancer and their effect on patient prognosis.

Conclusion

This work provides new insights into the mechanism of m6A methylation in ovarian cancer.

Results

We obtained 1408 genes dysregulated in parallel to m6A regulators, which were mainly involved in the platelet activation pathway. The m6A-related signature was constructed based on the expression of four prognosis-related genes (RPS6KA2, JUNB, HNF4A and P2RX1).

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