Abstract
Frailty and the consequent risk of falls represent significant challenges for community-dwelling older adults, often leading to severe injuries, functional decline, and loss of independence. Falls typically result from multiple interacting risk factors, many of which are modifiable through targeted interventions. This mini-review focuses on evidence from randomized controlled trials evaluating effective therapeutic strategies to prevent frailty and falls. Comprehensive assessment and management of modifiable risk factors have been shown to significantly reduce fall incidence. Key interventions include community-based and home-based exercise programs emphasizing balance and strength training. Additionally, the treatment of osteoporosis is crucial to reducing the risk of fall-related fractures. Other modifiable risk factors, such as orthostatic hypotension, polypharmacy, environmental hazards, osteoporosis, malnutrition, and cognitive impairment, require targeted assessment and intervention. Despite these advances, further research is needed to optimize multifactorial interventions and tailor strategies to individual risk profiles. Innovative research directions now span from micro to macro levels, incorporating insights from animal models to human studies, aiming to unravel underlying mechanisms and develop personalized therapeutic strategies. This review discusses emerging evidence and new interdisciplinary research avenues that offer hope for mitigating frailty and preventing falls in community-dwelling older adults.