Abstract
BACKGROUND: The association of novel anthropometrics and novel atherogenicity indices with mortality remains uncertain. OBJECTIVE: To compare the association of novel anthropometrics and atherogenicity indices with all-cause, cardiovascular (CVD), and non-CVD mortality in Iranian adults. METHODS: Utilizing data from Isfahan Cohort Study, 5432 participants aged older than 35 years were enrolled. Three anthropometrics indices including a body shape index (ABSI), body roundness index (BRI) and abdominal volume index (AVI), and three atherogenicity indices including atherogenic index of plasma (AIP), Castelli risk index (CRI) and the cholesterol index (CI) were calculated. Cox proportional hazards regression models were used to explore the association between indices and mortality. RESULTS: After a median follow-up of 11.25 years, the ABSI was independently associated with increased risk of all-cause mortality (HR(Q4) (vs. Q1) = 1.43, 95 % CI: 1.07, 1.92; P trend = 0.02). A positive, independent association was also observed between CRI-II (HR(Q4) (vs. Q1) = 1.49, 95 % CI: 0.99, 2.25; P trend = 0.04) and AIP (HR(Q4) (vs. Q1) = 1.81, 95 % CI: 1.92, 2.27; P trend = 0.01) and CVD mortality. For non-CVD mortality, despite a direct link for ABSI (HR(Q4) (vs. Q1) = 1.92, 95 % CI: 1.32, 2.80; P trend = 0.001), an inverse association was found for CI (HR(Q4) (vs. Q1) = 0.68, 95 % CI: 0.49, 0.95; P trend = 0.007). CONCLUSION: Amongst various investigated anthropometric indices, ABSI was directly related to all-cause and non-CVD mortality. However, atherogenicity indices including CRI-II and AIP could predict the incidence risk of CVD mortality among Iranians. Further studies are warranted to confirm these findings.