Saving KLF2/4 from γ-protocadherin to reduce vascular inflammation and atherosclerosis

Atherosclerosis occurs in arterial regions exposed to disturbed flow, where endothelial expression of flow-sensitive, atheroprotective genes such as KLF2 and KLF4 is reduced. Protecting the endothelial expression of KLF2 and KLF4 from inhibitory factors could be a therapeutic approach to prevent vascular inflammation and atherosclerosis.