Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using Box Behnken design

使用 Box Behnken 设计配制和优化伊曲康唑聚合物脂质混合纳米颗粒 (Lipomer)

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作者:Balaram Gajra, Chintan Dalwadi, Ravi Patel

Background

The

Conclusion

The tunable particle size, surface charge, and favourable encapsulation efficiency with a sustained drug release profile of PLHNs suggesting that it could be promising system envisioned to increase the bioavailability by improving intestinal permeability through lymphatic uptake, M cell of payer's patch or paracellular pathway which was proven by confocal microscopy.

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